Messenger RNA delivery of a dual CD25/CD122 affinity-tuned IL-2 variant prolongs exposure and potentiates antitumor T ...
RESULTS IL-2 variants with partially retained IL-2Rα binding and increased IL-2Rβ binding selectively enhance stimulation of CD8+ effector T cells in culture and in mice To identify an IL-2 variant with enhanced affinity for IL-2Rβ and reduced affinity for …